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When compared to a Gi/o-coupled GPCR from the same family, we found our chimera exhibited the same signalling profile: full activation of Gi/o proteins but no Gq activation, and GIRK-mediated potassium conductance of the same magnitude (Gi/o-coupled GPCR -36.39±2.872pA/pF n=7
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10.1021/acsbiomaterials.2c01431 46
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