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One injectable exposure is documented: a 50-year-old woman self-injected 132 mg after a reconstitution error, 66 times her intended 2 mg, and was asymptomatic when she presented.¹⁴ No copper, ceruloplasmin, kidney, or liver testing was reported
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These limitations must be addressed through advanced formulation strategies (eg, nanoparticle encapsulation, prodrug design) or structural optimization
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